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Innately Water-Soluble Isatoic Anhydrides with Modulated Reactivities for RNA SHAPE Analysis.

Adam B Fessler, Abhishek Dey, Dominic S Finis

  • 1NuChemie, LLC, Charlotte, North Carolina 28227, United States.

Bioconjugate Chemistry
|February 11, 2020
PubMed
Summary

New water-soluble isatoic anhydride reagents offer variable reactivity for RNA structural probing. These novel electrophiles overcome the solubility limitations of existing reagents like 1-Methyl-7-nitroisatoic anhydride (1M7).

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