Integral estimation of systemic inflammatory response under sepsis.

Area of Science:

• Biochemistry
• Clinical Medicine
• Immunology

Background:

• Systemic inflammatory response (SIR) is critical in sepsis development.
• Chaotic blood concentration changes of mediators complicate SIR assessment.
• Integral indicators are needed for accurate SIR evaluation in sepsis.

Purpose of the Study:

• To develop and validate a scoring scale for SIR in sepsis.
• To assess the relationship between SIR severity and critical sepsis complications.
• To evaluate SIR in different sepsis phenotypes, including prolonged sepsis.

Main Methods:

• A scoring scale (0-16 points) was created using CRP, TNF-α, IL-6, IL-8, and IL-10 levels.
• The scale was applied to 167 sepsis patients (Sepsis-1/2 and Sepsis-3 criteria).
• Patient outcomes included septic shock (31 cases) and mortality (48 cases).

Main Results:

• The SIR scale demonstrated an association with critical sepsis complications.
• Stronger correlation observed with acute septic shock and early (days 5-7) complications.
• Prolonged sepsis (>14 days) with tertiary peritonitis showed less dependence on SIR severity.

Conclusions:

• The proposed SIR scoring scale offers a valuable tool for assessing sepsis severity.
• The scale aids in predicting critical complications, especially in acute sepsis.
• The scale's open nature allows for future modifications and inclusion of other relevant biomarkers.