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Published on: September 12, 2014
Histopathological Study of an Explanted Novel Artificial Corneal Device
Marjan Farid1, Sara Sabeti, Donald S Minckler
1Department of Ophthalmology, University of California, Irvine School of Medicine, Irvine, CA.
Purpose:
To report the first histopathological examination of an explanted KeraKlear keratoprosthesis device and surrounding host corneal tissue 1 year after transplantation.
Methods:
An explanted KeraKlear artificial cornea was evaluated by histopathology to assess for tissue integration and corneal remolding.
Results:
Histopathological examination revealed collagenous ingrowth between the anterior and posterior corneal stromal lamellae through the holes in the device skirt. Hematoxylin and eosin stain (H&E), periodic acid Schiff (PAS), and Masson trichrome stains demonstrated no significant inflammation, vascularization, or edema.
Conclusions:
The KeraKlear artificial corneal device seems to be a biocompatible alternative to donor corneal tissues for visual rehabilitation for suitable patients.
