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Primordial odontogenic tumor: A systematic review
R Bologna-Molina1, V Pereira-Prado, C Sánchez-Romero
1Health Care Department Universidad Autónoma Metropolitana Calzada del Hueso 1100, Col Villa Quietud Delg. Coyaoacan, C.P.04960 Ciudad de México mosqueda@correo.xoc.uam.mx.
Medicina Oral, Patologia Oral Y Cirugia Bucal
|February 11, 2020
Summary
Primordial odontogenic tumor (POT) is a rare benign tumor originating in early tooth development. This analysis defines its clinicopathological and molecular features, aiding diagnosis and differentiation from other odontogenic lesions.
Area of Science:
- Oral Pathology
- Odontogenesis
- Tumor Biology
Background:
- Primordial odontogenic tumor (POT) is a recently identified benign entity.
- Its histopathological and immunohistochemical features suggest an origin during early odontogenesis.
Purpose of the Study:
- To comprehensively analyze available data on POT.
- To better define the clinicopathological and molecular characteristics of POT.
Main Methods:
- An electronic systematic review of publications up to September 2019 was conducted.
- Included 13 publications representing 16 cases and 3 molecular studies.
Main Results:
- POT predominantly affects the posterior mandible in adolescents (mean age 11.6 years), appearing as a radiolucent lesion near unerupted teeth.
- Histologically, it features fibromyxoid tissue and odontogenic epithelium without hard tissue formation.
- Immunohistochemistry reveals specific markers (e.g., amelogenin, CK19, Vimentin) and a low Ki-67 index (<5%), with absent hard tissue formation potentially due to specific gene expression.
Conclusions:
- POT possesses a distinct clinicopathological, immunohistochemical, and molecular profile.
- Accurate diagnosis and differentiation from other odontogenic lesions are crucial for appropriate management.
