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Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review.
Mahshid Moballegh Nasery1,2,3, Banafshe Abadi1, Delaram Poormoghadam4
1Student Research Committee, Kerman University of Medical Sciences, Kerman 7619813159, Iran.
Molecules (Basel, Switzerland)
|February 12, 2020
Summary
Nano-pharmaceutics enhances drug efficacy, particularly for nutraceuticals like curcumin. Encapsulating curcumin in bio-nanocarriers improves its poor solubility and bioavailability for better therapeutic outcomes.
Area of Science:
- Nanomedicine and Pharmaceutical Sciences
- Natural Product Chemistry
- Biotechnology
Background:
- Nutraceuticals show promise for chronic diseases but face challenges in solubility, bioavailability, and biodegradability.
- Curcumin, a polyphenol with diverse pharmacological activities (anti-inflammatory, anti-carcinogenic, anti-viral), suffers from poor solubility and bioavailability, limiting its clinical use.
Purpose of the Study:
- To review the therapeutic applications of curcumin.
- To explore the potential of bio-nanocarrier systems for effective curcumin delivery.
- To address the limitations of curcumin's solubility and bioavailability through nanocarrier formulations.
Main Methods:
- Literature review focusing on nano-pharmaceutics and curcumin delivery systems.
- Analysis of different types of biological and biopolymer nanocarriers.
- Discussion of curcumin's pharmacological activities and challenges.
Main Results:
- Nano-pharmaceutics offers solutions to improve drug efficacy and overcome limitations of natural compounds.
- Bio-nanocarriers present a promising strategy for enhancing curcumin's solubility and bioavailability.
- Encapsulation in nanocarriers can significantly improve the therapeutic potential of curcumin.
Conclusions:
- Curcumin's therapeutic benefits can be better realized through nano-formulations.
- Bio-nanocarriers are effective delivery systems for improving curcumin's pharmacokinetic profile.
- This review highlights the importance of nanocarrier-mediated delivery for optimizing nutraceutical efficacy.
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