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Updated: Dec 28, 2025

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
Published on: December 8, 2017
Immune cell regulation of glia during CNS injury and disease
Andrew D Greenhalgh1, Sam David2, F Chris Bennett3
1INRA, Laboratoire Nutrition et Neurobiologie Intégrée, University of Bordeaux, Bordeaux, France. adgreenhalgh@gmail.com.
Abstract:
Glial cells are abundant in the CNS and are essential for brain development and homeostasis. These cells also regulate tissue recovery after injury and their dysfunction is a possible contributing factor to neurodegenerative and psychiatric disease. Recent evidence suggests that microglia, which are also the brain's major resident immune cells, provide disease-modifying regulation of the other major glial populations, namely astrocytes and oligodendrocytes. In addition, peripheral immune cells entering the CNS after injury and in disease may directly affect microglial, astrocyte and oligodendrocyte function, suggesting an integrated network of immune cell-glial cell communication.
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