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Physical activity and laryngeal cancer
Riccardo Nocini1, Fabian Sanchis-Gomar2, Giuseppe Lippi3
1Section of Ears, Nose and Throat (ENT), Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.
Engaging in moderate-intensity physical activity (PA) may reduce laryngeal cancer risk and improve survival. High-intensity PA effects are less clear, but moderate activity offers significant benefits for cancer prevention and survivor quality of life.
Area of Science:
- Oncology
- Epidemiology
- Exercise Physiology
Background:
- An active lifestyle is linked to reduced cancer risk, but the association with laryngeal carcinogenesis is uncertain.
- Epidemiologic studies show varied effects of physical activity (PA) on laryngeal cancer risk, unlike other malignancies.
- Moderate-intensity PA appears more beneficial than high-intensity PA for lowering cancer risk.
Purpose of the Study:
- To investigate the relationship between physical activity and laryngeal cancer.
- To clarify the differential effects of moderate- vs. high-intensity PA on laryngeal carcinogenesis.
- To explore the benefits of PA for laryngeal cancer survivors.
Main Methods:
- Review of epidemiologic evidence from cross-sectional, prospective, and retrospective studies.
- Analysis of PA intensity's impact on laryngeal cancer risk factors.
- Assessment of moderate-intensity exercise benefits for cancer survivors.
Main Results:
- Moderate-intensity PA shows potential benefits in reducing laryngeal cancer risk.
- High-intensity PA's effect on laryngeal cancer risk is controversial and contradictory.
- Moderate PA may mitigate risk factors like metabolic syndrome, smoking, inflammation, and GERD.
- Moderate exercise offers biological and psychological benefits to laryngeal cancer survivors.
Conclusions:
- Promoting moderate-intensity PA (3-6 METs) may lower laryngeal cancer development risk.
- An active lifestyle with moderate PA can improve the quality of life for larynx cancer survivors.
- Moderate PA is recommended for both primary prevention and post-treatment recovery in laryngeal cancer.
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