Related Experiment Video
Updated: Aug 4, 2026

08:03
In Vivo Mouse Model of Spinal Implant Infection
Published on: June 23, 2020
2.7K
M6-C cervical disc replacement failure associated with late onset infection
Mary-Anne M Xia1, Mark J Winder1
1Department of Neurosurgery, St Vincent's Private Hospital, Sydney, NSW, Australia.
Journal of Spine Surgery (Hong Kong)
|February 12, 2020
Summary
Cervical disc replacement can fail due to infection. This case shows an M6-C device failure linked to Propionibacterium acnes infection three years after surgery.
Area of Science:
- Spine surgery
- Infectious disease
Background:
- Cervical disc replacement is a common treatment for degenerative disc disease.
- Artificial disc prostheses are widely used in spinal reconstructive surgery.
Observation:
- A case of M6-C cervical disc replacement failure is presented.
- The failure occurred three years after the initial implantation surgery.
Findings:
- The failed M6-C disc replacement was associated with Propionibacterium acnes infection.
- Propionibacterium acnes is a known opportunistic pathogen.
Implications:
- This case highlights the risk of late-onset infection following cervical disc replacement.
- Propionibacterium acnes should be considered in the differential diagnosis of late-onset spinal implant infections.
- Further research into preventing and managing late-onset infections after disc arthroplasty is warranted.
Related Concept Videos
Herniated Intervertebral Disc l: Introduction
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease I: Introduction
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Degenerative Disc Disease ll: Pathophysiology
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

