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Updated: Dec 28, 2025
From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94
Sho Kato1,2, Takayuki Motoyama1, Yushi Futamura1
1Chemical Biology Research Group, RIKEN CSRS, Wako, Saitama, Japan.
Abstract:
We identified the biosynthetic gene cluster for lucilactaene, a cell cycle inhibitor from a filamentous fungus Fusarium sp. RK 97-94. The luc1 knockout strain accumulated demethylated analogs, indicating the involvement of Luc1 methyltransferase in lucilactaene biosynthesis. Lucilactaene showed potent antimalarial activity. Our data suggested that methylation and ether ring formation are essential for its potent antimalarial activity.
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