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Updated: Dec 28, 2025

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
High tidal volume ventilation is associated with ventilator-associated pneumonia in acute cervical spinal cord injury
Gabrielle E Hatton1,2,3, Patrick J Mollett4, Reginald E Du1,5
1Center for Translational Injury Research, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas, USA.
Context/Objective:
Pneumonia is the leading cause of death after acute spinal cord injury (SCI). High tidal volume ventilation (HVtV) is used in SCI rehabilitation centers to overcome hypoventilation while weaning patients from the ventilator. Our objective was to determine if HVtV in the acute post-injury period in SCI patients is associated with lower incidence of ventilator-associated pneumonia (VAP) when compared to patients receiving standard tidal volume ventilation.
Design:
Cohort study.
Setting:
Red Duke Trauma Institute, University of Texas Health Science Center at Houston, TX, USA.
Participants:
Adult Acute Cervical SCI Patients, 2011-2018.
Interventions:
HVtV.
Outcome Measures:
VAP, ventilator dependence at discharge, in-hospital mortality.
Results:
Of 181 patients, 85 (47%) developed VAP. HVtV was utilized in 22 (12%) patients. Demographics, apart from age, were similar between patients who received HVtV and standard ventilation; patients were younger in the HVtV group. VAP developed in 68% of patients receiving HVtV and in 44% receiving standard tidal volumes (P = 0.06). After adjustment, HVtV was associated with a 1.96 relative risk of VAP development (95% credible interval 1.55-2.17) on Bayesian analysis. These results correlate with a >99% posterior probability that HVtV is associated with increased VAP when compared to standard tidal volumes. HVtV was also associated with increased rates of ventilator dependence.
Conclusions:
While limited by sample size and selection bias, our data revealed an association between HVtV and increased VAP. Further investigation into optimal early ventilation settings is needed for SCI patients, who are at a high risk of VAP.
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