Evidence for joint genic control of spontaneous mutation and genetic recombination during mitosis in Saccharomyces

A procedure for detection of mutants exhibiting either enhanced or reduced spontaneous mutation during mitosis and/or meiosis has been developed to probe the joint genic control of spontaneous mutation and recombination in yeast. A semidominant mutator, rem1-1, recovered by this technique, exhibits enhanced spontaneous mutation,intragenic recombination, and intergenic recombination during mitosis. Diploids homozygous for rem1-1 exhibit normal levels of meiotic intragenic and intergenic recombination and diminished ascospore viability.