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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
375
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

361
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
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Modern surgery for ulcerative colitis.

Brenda Murphy1,2, Dara Oliver Kavanagh3,4, Desmond Colm Winter5

  • 1Departments of Colorectal Surgery, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland. murphb14@tcd.ie.

Updates in Surgery
|February 13, 2020
PubMed
Summary
This summary is machine-generated.

Ulcerative colitis (UC) management often involves surgery for about 10% of patients. This review explores current surgical options and diverse practices for UC colectomy.

Keywords:
IPAAPanproctocolectomySubtotal colectomyTotal colectomyUCUlcerative colitis

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Area of Science:

  • Gastroenterology
  • Surgical Gastroenterology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown causes.
  • Medical therapy is the primary treatment for UC, but colectomy is necessary for approximately 10% of patients.

Purpose of the Study:

  • To review modern surgical practices for ulcerative colitis.
  • To address current controversies and variations in surgical approaches for UC.

Main Methods:

  • Literature review of contemporary surgical techniques for ulcerative colitis.
  • Analysis of factors influencing surgical decision-making in UC patients.

Main Results:

  • Multiple surgical options exist for UC, with choices varying based on clinical factors and patient/surgeon preferences.
  • Current surgical strategies for UC involve diverse approaches and ongoing debates.

Conclusions:

  • Surgical management of ulcerative colitis is multifaceted.
  • The selection of surgical procedures for UC is individualized, reflecting a range of contemporary practices and unresolved issues.