Related Experiment Video
Updated: Dec 28, 2025
Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
Published on: July 21, 2013
Reversible Lesion of the Corpus Callosum in a Patient With Migraine With Aura: A Case Study
Richard Lewis1, Armando Ruiz2, Teshamae Monteith3
1Neurology, Jackson Memorial Hospital, Miami, FL, USA.
Objective:
To describe a patient with migraine with aura (MWA) who was found to have a reversible lesion of the corpus callosum.
Background:
Reversible lesions of the splenium of the corpus callosum are well-described clinical-radiographic phenomena, which have been associated with a wide array of disease states, including epilepsy, demyelinating disease, infection, and metabolic derangements. There have been few case reports in the literature to date of these lesions associated with migraine headache.
Design/Methods:
A case report.
Results:
A 41 year-old female with a history of migraine with visual aura presented with headache associated with left-sided sensorimotor deficits. Routine laboratory tests were within normal limits. An electroencephlogram was also normal. Magnetic resonance imaging (MRI) of the brain with and without contrast revealed areas of restricted diffusion in the splenium and the genu of the corpus callosum. The patient's symptoms resolved after 2 days. A follow-up MRI 2 days after the onset of symptoms revealed resolution of the callosal lesions. The patient was diagnosed clinically with migraine with prolonged aura.
Conclusion:
MWA may be associated with reversible lesions of the corpus callosum.
Insights
Migraine with aura (MWA) can be linked to temporary corpus callosum lesions. These reversible brain changes, seen on MRI, resolved quickly in a patient with prolonged aura symptoms.
Area of Science:
- Neurology
- Radiology
- Neuroimaging
Background:
- Reversible splenium corpus callosum lesions are known in various conditions like epilepsy and infections.
- Such lesions are rarely reported in association with migraine headaches.
Observation:
- A 41-year-old female with migraine with aura presented with headache and transient left-sided sensorimotor deficits.
- Brain MRI revealed restricted diffusion in the corpus callosum's splenium and genu, resolving within 4 days.
Findings:
- The patient's neurological symptoms and corpus callosum lesions resolved spontaneously.
- Diagnosis was migraine with prolonged aura, highlighting a potential association with reversible callosal changes.
Implications:
- This case suggests migraine with aura may present with reversible corpus callosum lesions.
- Further research is needed to understand the mechanism and clinical significance of these MRI findings in MWA.
