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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Updated: Dec 28, 2025

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

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Published on: March 13, 2018

Radiotracer Development for Bacterial Imaging.

Filipa Mota^1,2,3, Alvaro A Ordonez^1,2,3, George Firth⁴

¹Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.

Journal of Medicinal Chemistry

|February 13, 2020

Summary

This summary is machine-generated.

New radiotracer imaging techniques offer hope for early diagnosis and monitoring of bacterial infections. This technology aids in understanding drug effectiveness and infection site biology, accelerating therapeutic development.

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Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

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Published on: December 15, 2017

Area of Science:

Medical Imaging
Radiochemistry
Infectious Diseases

Background:

Bacterial infections pose a significant global health threat, exacerbated by rising antimicrobial resistance.
Early diagnosis and monitoring of deep-seated infections in hospitalized patients are critical challenges.
The World Health Organization identifies antimicrobial resistance as a top ten human health threat.

Purpose of the Study:

To review the application of radiotracers for imaging bacterial infections.
To summarize advancements in pathogen-specific imaging and radiotracer use in drug pharmacokinetics and local infection biology.
To highlight opportunities for medicinal chemists in developing novel radiotracers for bacterial infections.

Main Methods:

Review of recent literature on radiotracer development for bacterial infection imaging.
Analysis of applications in understanding drug pharmacokinetics and infection site biology.
Emphasis on target selection and radiosynthetic approaches for radiotracer design.

Main Results:

Radiotracers are increasingly used for pathogen-specific imaging of bacterial infections.
These agents provide insights into drug pharmacokinetics and the local biology of infection sites.
Advancements facilitate the development of new diagnostic and therapeutic strategies.

Conclusions:

Radiotracer imaging is an emerging field with significant potential for diagnosing and monitoring bacterial infections.
This technology can deepen our understanding of disease pathogenesis.
It promises to accelerate the translation of new therapeutics from the lab to the clinic.