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Related Concept Videos

Birth Control Methods01:22

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Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
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The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
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The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
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The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
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Hormonal Male Contraception.

Aleksander Giwercman1

  • 1Dept. Of Translational Medicine, Lund University, Malmo, Sweden.

Current Pharmaceutical Design
|February 13, 2020
PubMed
Summary
This summary is machine-generated.

Developing safe and effective male contraception is crucial for shared family planning. Hormonal manipulation to suppress sperm production is a promising, though not yet fully realized, approach for male birth control.

Keywords:
Maleazoospermiacontraceptiongestagensgonadotropins.hormonalsemen qualityside effectstestosterone

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Area of Science:

  • Reproductive Endocrinology
  • Contraceptive Development

Background:

  • Growing global population necessitates equitable family planning solutions.
  • Women disproportionately bear the burden of contraception and unintended pregnancies.
  • Men express a desire to share contraceptive responsibilities.

Purpose of the Study:

  • To explore the feasibility of hormonal male contraception.
  • To address the need for safe, effective, and reversible male birth control methods.

Main Methods:

  • Investigating hormonal manipulation strategies for sperm production suppression.
  • Utilizing exogenous testosterone administration, alone or with endocrine suppressors.

Main Results:

  • Hormonal approaches aim to reversibly inhibit spermatogenesis.
  • Current methods, often involving testosterone, have not yet fully met all desired criteria.
  • Ongoing research focuses on novel molecules for improved efficacy and safety.

Conclusions:

  • Hormonal male contraception remains an active area of research.
  • Developing ideal male contraceptive agents requires further innovation.
  • Future advancements hold promise for achieving effective male birth control.