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Left Ventricular Remodeling Patterns in Primary Healthcare

Roberto de Castro Meirelles de Almeida1, Antonio José Lagoeiro Jorge1, Maria Luiza Garcia Rosa1

  • 1Curso de Pós-Graduação em Ciências Cardiovasculares da Universidade Federal Fluminense (UFF), Niterói, RJ - Brazil.

Arquivos Brasileiros De Cardiologia
|February 13, 2020
PubMed

Insights

Left ventricular remodeling (LVR) affects one-third of adults and is linked to heart failure risk. Altered albumin/creatinine ratio in urine is associated with eccentric hypertrophy, suggesting early cardiac and renal dysfunction.

Area of Science:

  • Cardiology
  • Nephrology
  • Echocardiography

Background:

  • Left ventricular remodeling (LVR) is a significant predictor of adverse non-fatal and fatal cardiovascular outcomes.
  • Understanding the geometric patterns of LVR is crucial for risk stratification and management.

Purpose of the Study:

  • To characterize the geometric patterns of left ventricular remodeling (LVR) in a Brazilian population.
  • To investigate the associations between LVR patterns and clinical/laboratory variables.

Main Methods:

  • A cross-sectional study involving 636 individuals aged 45-99 years in Rio de Janeiro, Brazil.
  • Evaluations included clinical assessment, laboratory tests, electrocardiogram, and tissue Doppler echocardiography (TDE).
  • Statistical analyses used Kruskal-Wallis, Pearson's Chi-square, and logistic regression to assess associations with LVR patterns (normal geometry, concentric remodeling, concentric hypertrophy, eccentric hypertrophy).

Main Results:

  • The prevalence of altered left ventricular geometry was 33%.
  • Eccentric hypertrophy (EH) was the most common altered pattern (29%), followed by concentric hypertrophy (2%) and concentric remodeling (2%).
  • Gender, age, education level, and albumin/creatinine ratio (A/C) were independently associated with the likelihood of EH.

Conclusions:

  • Approximately one-third of the study cohort exhibited left ventricular remodeling, placing them at risk for heart failure.
  • An altered urinary albumin/creatinine ratio was linked to eccentric hypertrophy, suggesting an early interplay between cardiac and renal dysfunction.
Abstract

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