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Related Concept Videos

Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

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Doppler Optical Coherence Tomography of Retinal Circulation
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Optical Coherence Tomography Angiography in Glaucoma.

Harsha L Rao1, Zia S Pradhan2, Min Hee Suh3

  • 1Narayana Nethralaya, Hulimavu.

Journal of Glaucoma
|February 14, 2020
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Summary

Optical coherence tomography angiography (OCTA) reveals reduced blood vessel density in glaucoma patients. This noninvasive imaging technique helps diagnose glaucoma and monitor disease progression.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Optical coherence tomography angiography (OCTA) is a novel, noninvasive imaging method.
  • It assesses retinal and optic nerve head vasculature without dyes.
  • OCTA visualizes the choriocapillaris, particularly in parapapillary atrophy areas.

Purpose of the Study:

  • To evaluate the utility of OCTA in diagnosing and monitoring glaucoma.
  • To correlate OCTA findings with functional and structural changes in glaucoma.
  • To assess the potential of OCTA for predicting glaucoma progression.

Main Methods:

  • Utilized OCTA to image the vasculature of the retina and optic nerve head.
  • Analyzed blood flow using red blood cell movement as contrast.
  • Correlated OCTA findings (vessel density, microvascular dropout) with visual field and OCT data.

Main Results:

  • OCTA showed reduced superficial vessel density and deep-layer microvascular dropout in glaucoma patients.
  • These OCTA changes correlated topographically with visual field and OCT structural changes.
  • OCTA measurements demonstrated good test-retest variability and ability to differentiate glaucomatous from normal eyes.

Conclusions:

  • OCTA is a valuable tool for diagnosing glaucoma and assessing disease progression.
  • OCTA findings correlate with established glaucoma metrics, offering complementary diagnostic information.
  • OCTA has the potential to monitor progression in advanced glaucoma and identify patients at risk.