Detection and quantification of renal fibrosis by computerized tomography
Related Experiment Video
Updated: Dec 28, 2025

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Eric P Cohen1,2, John D Olson3, Janet A Tooze3
1Department of Medicine, University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America.
Objectives:
Reliable biomarkers for renal fibrosis are needed for clinical care and for research. Existing non-invasive biomarkers are imprecise, which has limited their utility.
Methods:
We developed a method to quantify fibrosis by subject size-adjusted CT Hounsfield units. This was accomplished using CT measurements of renal cortex in previously irradiated non-human primates.
Results:
Renal cortex mean CT Hounsfield units that were adjusted for body size had a very good direct correlation with renal parenchymal fibrosis, with an area under the curve of 0.93.
Conclusions:
This metric is a promising and simple non-invasive biomarker for renal fibrosis.
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