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Related Concept Videos

Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

937
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
937

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Ultrafast Time-resolved Near-IR Stimulated Raman Measurements of Functional π-conjugate Systems
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A Miniature Fibre-Optic Raman Probe Fabricated by Ultrafast Laser-Assisted Etching.

Calum A Ross1, David G MacLachlan1, Brian J E Smith2

  • 1Scottish Universities Physics Alliance (SUPA), Institute of Photonics and Quantum Sciences (IPaQS), Heriot-Watt University, Edinburgh EH14 4AS, UK.

Micromachines
|February 15, 2020
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Summary

We developed a novel, compact micro-optic system for Raman spectroscopy optical biopsies. This scalable technology improves signal collection efficiency for better disease diagnosis.

Keywords:
Raman spectroscopymicro-opticsoptical biopsyultrafast laser-assisted etching

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Area of Science:

  • Biomedical Optics
  • Spectroscopy
  • Medical Devices

Background:

  • Optical biopsy uses light for disease investigation, offering advantages over traditional methods.
  • Raman spectroscopy enables molecular-level tissue differentiation for cancer staging.
  • Current Raman probes require complex micro-optics, hindering large-scale adoption.

Purpose of the Study:

  • To introduce a novel fibre-fed micro-optic system for enhanced Raman spectroscopy optical biopsies.
  • To address the manufacturing challenges of micro-optical systems for improved signal collection.

Main Methods:

  • Fabrication of a sub-millimetre diameter Raman probe using ultrafast laser-assisted etching.
  • Development of a fibre-fed micro-optic system for efficient signal delivery and collection.
  • Passive alignment of optical components via direct-laser-writing.

Main Results:

  • Achieved confocal signal collection with 71.3% ± 1.5% efficiency at a 0.8 numerical aperture.
  • Demonstrated proof-of-concept spectral measurements on mouse intestinal tissue.
  • Compared favorably with a commercial Raman microscope.

Conclusions:

  • The novel micro-optic system offers efficient signal collection for Raman spectroscopy optical biopsies.
  • Ultrafast laser-assisted etching provides a scalable manufacturing method for these devices.
  • This technology has potential for improved diagnostic capabilities in hard-to-reach areas.