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A Review on Stem Cell Therapy for Neuropathic Pain
Samira Asgharzade1, Andisheh Talaei2, Tahereh Farkhondeh3
1Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Current Stem Cell Research & Therapy
|February 15, 2020
Summary
Stem cell transplantation shows promise for treating neuropathic pain, a complex condition with limited treatment options. This therapy could offer a novel approach by replacing damaged cells and providing beneficial factors at the injury site.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Pain Management
Background:
- Neuropathic pain is a challenging chronic pain condition resulting from somatosensory system damage.
- Existing treatments offer limited relief and significant side effects for many patients.
- Stem cell transplantation is an emerging therapeutic strategy for various diseases.
Purpose of the Study:
- To review the therapeutic potential of stem cell transplantation for neuropathic pain.
- To examine different stem cell types, origins, and species in various neuropathic pain models.
Main Methods:
- Literature review of studies on stem cell transplantation in neuropathic pain models.
- Analysis of stem cell differentiation, trophic factor delivery, and migration to lesion sites.
Main Results:
- Stem cell transplantation demonstrated efficacy in alleviating neuropathic pain across different models.
- Stem cells possess the capacity for differentiation and secretion of supportive factors.
- The migratory and supportive functions of stem cells contribute to mitigating pain effects.
Conclusions:
- Stem cell therapy presents a promising novel therapeutic avenue for neuropathic pain.
- Further research into stem cell mechanisms and applications is warranted.
- This approach offers potential for improved patient outcomes in neuropathic pain management.
