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Three new triterpenoids from Mallotus macrostachyus.

Hui-Min Gao¹, Tian Wang¹, Hai-Tao Hu¹

¹Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.

|February 15, 2020

Summary

Researchers discovered three new triterpenoids, mallomacrostins A-C, from Mallotus macrostachyus. Two compounds showed significant anti-inflammatory effects by inhibiting nitric oxide release.

Keywords:

Anti-inflammatory activity Mallotus macrostachyus Structure elucidation Triterpenoids

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Area of Science:

Natural Products Chemistry
Pharmacology

Background:

Mallotus macrostachyus is a plant source of bioactive compounds.
Triterpenoids are a diverse class of natural products with various biological activities.

Purpose of the Study:

To isolate and characterize new triterpenoids from Mallotus macrostachyus.
To evaluate the anti-inflammatory potential of isolated compounds.

Main Methods:

Phytochemical investigation of Mallotus macrostachyus twigs and leaves.
Structure elucidation using HR-ESIMS, NMR, and X-ray diffraction.
In vitro anti-inflammatory assay measuring nitric oxide inhibition.

Main Results:

Three new triterpenoids, mallomacrostins A-C (1-3), and eleven known triterpenoids were identified.
Mallomacrostin A features a novel trinor-D:B-friedobaccharane skeleton.
Compounds 2 and 10 demonstrated significant anti-inflammatory activity, inhibiting nitric oxide release with IC50 values of 70.0 μM and 14.0 μM, respectively.

Conclusions:

The study expands the knowledge of triterpenoids from Mallotus macrostachyus, including a novel skeleton.
Mallomacrostins A-C represent new chemical entities with potential therapeutic applications.
Compounds 2 and 10 show promise as anti-inflammatory agents.