Some insights into the variations in antipyrine pharmacokinetics in the rat

Antipyrine plasma disposition and urinary metabolic profile studies conducted in this laboratory between 1984 and 1987 are reported. A comparison of this data is made to a previous report of temporal variation in antipyrine plasma disposition parameters over a 18 month period. It is suggested that antipyrine plasma disposition parameters may not be sensitive indicators of temporal variation, but that variation in the metabolic profile might provide such evidence.