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Sleep disorders in children and adolescents on regular hemodialysis

Nevine El-Baroudy1, Mona El Falaki1, Amal Hagras2

  • 1Pediatric Department, Cairo University, Cairo, Egypt.

European Journal of Pediatrics
|February 16, 2020
PubMed

Insights

Poor sleep quality is common in children undergoing hemodialysis, with kidney dysfunction strongly linked to sleep disturbances. Serum creatinine levels independently predict reduced sleep efficiency in these young patients.

Area of Science:

  • Pediatric Nephrology
  • Sleep Medicine
  • Clinical Research

Background:

  • Sleep disturbances negatively impact children's daytime functioning.
  • Limited research exists on sleep disorders in pediatric chronic kidney disease (CKD).

Purpose of the Study:

  • To characterize sleep disorders in children on regular hemodialysis (HD).
  • To identify predictors of sleep efficiency in pediatric HD patients.

Main Methods:

  • Compared 40 pediatric HD patients with 40 age/gender-matched controls.
  • Utilized questionnaires (Epworth Sleepiness Scale) and overnight polysomnography.
  • Assessed sleep efficiency, sleep staging, apnea/hypopnea index, and periodic limb movement index.

Main Results:

  • 20% of HD children had poor sleep efficiency; 45% had elevated periodic limb movement index; 40% had elevated apnea/hypopnea index.
  • Sleep efficiency correlated negatively with serum potassium, creatinine, and sleep onset.
  • Serum creatinine was the sole independent predictor of sleep efficiency.

Conclusions:

  • Poor sleep quality is prevalent in children on hemodialysis.
  • Kidney dysfunction is strongly associated with diminished sleep quality in pediatric HD patients.
  • Findings suggest a lower frequency of sleep disorders than previously reported.

Keywords:
AHIHemodialysisPLMISleep efficiencySleep quality

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