Related Experiment Video

Updated: Jun 23, 2025

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
05:57

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

8.5K

Early topical mitomycin-C prevents stricture formation in children with caustic ingestion

Happy Sawires1, Ayman Aeskander2, Manal El-Sayed1

  • 1Pediatric Department, Cairo University, Giza, Egypt.

Journal of Paediatrics and Child Health
|June 14, 2024
PubMed

Insights

Early topical application of mitomycin C (MMC) significantly reduced esophageal strictures in children after corrosive ingestion. This treatment proved safe and effective, decreasing the need for dilatations compared to conventional management.

Area of Science:

  • Pediatric Gastroenterology
  • Otolaryngology
  • Toxicology

Background:

  • Caustic ingestion in children frequently leads to esophageal strictures, a common long-term complication.
  • Current management often involves repeated endoscopic dilatations, which can be burdensome and less effective.

Purpose of the Study:

  • To evaluate the efficacy and safety of early topical endoscopic application of mitomycin C (MMC) in preventing stricture formation after caustic ingestion in pediatric patients.

Main Methods:

  • A prospective, randomized-controlled study included 78 children with recent caustic ingestion; 61 completed the study.
  • Group A (30 children) received topical MMC within 48 hours, while Group B (31 children) received conventional management.
  • Both groups underwent follow-up endoscopic dilatations as needed.

Main Results:

  • Only 30% of children treated with early MMC developed strictures, compared to 100% in the conventional management group (P < 0.001).
  • The MMC group required zero median dilatations, versus 26 in the conventional group (P < 0.001).
  • Early MMC application achieved an 86.7% complete response rate, significantly higher than conventional therapy (35.5%).

Conclusions:

  • Early topical mitomycin C application is an effective and safe strategy for preventing esophageal strictures and scar formation in children following corrosive ingestion.
  • This approach reduces the need for subsequent endoscopic interventions.
Abstract

Keywords:
causticsendoscopymitomycinpreventionscar formation

More Related Videos

Surgical Management of Meatal Stenosis with Meatoplasty04:53

Surgical Management of Meatal Stenosis with Meatoplasty

Published on: November 30, 2010

52.6K
Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model05:09

Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model

Published on: April 28, 2023

939

Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
81
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
440
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
87
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
139
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
54