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Updated: May 18, 2026

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease
Published on: July 19, 2024
Metabolic Dysfunction-Associated Steatotic Liver Disease in Africa: From Burden to Action
Mohamed El-Kassas1, C Wendy Spearman2, Manal El-Sayed3
1Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt; The Global NASH/MASH Council, Washington DC, USA.
Abstract:
Metabolic dysfunction-associated steatotic liver disease and steatohepatitis are rising across Africa, driven by obesity, diabetes, urbanization, and social determinants, with regional heterogeneity. North Africa shows the highest prevalence, while several sub-Saharan regions have the fastest growth. Coexisting hepatitis B virus, hepatitis C virus, and HIV accelerate fibrosis and complicate hepatocellular carcinoma surveillance. A scalable response is resource stratified triage from non-hepatology settings using FIB-4 with age-adjusted cutoffs, selective elastography, and clear referral thresholds, integrated into noncommunicable disease programs; management prioritizes weight loss, cardiometabolic control, and access to effective therapies.
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