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Updated: Dec 28, 2025

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Published on: May 29, 2015
Reduced E-cadherin expression as a prognostic factor in non-muscle-invasive bladder cancer: A systematic review and
1Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, 710061 Xi'an, PR China.
Introduction And Objectives:
The exact role of E-cadherin in non-muscle-invasive bladder cancer (NMIBC) is still unknown, and the aims of this study were to prove whether reduced E-cadherin expression can be a prognostic factor in patients with NMIBC.
Materials And Methods:
A meta-analysis was conducted to assess the prognostic value of reduced E-cadherin expression in NMIBC. The PubMed, Embase and Web of Science databases were included in the study search.
Results:
Fifteen studies with a total of 1538 NMIBC patients were included. The results showed that reduced E-cadherin expression was significantly associated with poor recurrence-free survival (RFS) (pooled HR 2.16, 95% CI 1.22-3.85) and progression-free survival (PFS) (pooled HR 1.91, 95% CI 1.52-2.40) in NMIBC patients.
Conclusion:
E-cadherin can be a prognostic factor for patients with NMIBC.
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