Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

6.6K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
6.6K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

3.5K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.5K
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

1.8K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
1.8K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

147
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
147
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

1.3K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.3K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

635
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
635

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design of an artificial intelligence model to screen spontaneous speech to detect Alzheimer's Disease.

PLOS digital health·2026
Same author

Exercise Snacks in Adults Living With Obesity: Protocol for a Randomized Feasibility Trial.

JMIR research protocols·2026
Same author

Exercise snacks performed in real-world settings reduce postprandial hyperglycaemia and glycaemic variability in individuals living with type 2 diabetes: a randomised crossover study.

Diabetologia·2026
Same author

Reference Values of Quadriceps Muscle Thickness Measured by Point-of-Care Ultrasound by Sex and Age Groups in Older Adults.

Canadian geriatrics journal : CGJ·2026
Same author

Association Between Sex-specific Handgrip Strength and Plasma Glycated Hemoglobin Levels Among Older Adults: A Cross-sectional Study.

Canadian journal of diabetes·2025
Same author

Association of point-of-care ultrasound-derived subcutaneous fat thickness with DXA-measured body fat percentage in older adults.

Diabetes, obesity & metabolism·2025

Related Experiment Video

Updated: Dec 28, 2025

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
09:56

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

5.8K

Baroreflex function and postprandial hypotension in older adults.

Kenneth M Madden1,2,3, Boris Feldman4, Graydon S Meneilly4

  • 1Gerontology and Diabetes Research Laboratory, Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. Kenneth.Madden@vch.ca.

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
|February 17, 2020
PubMed
Summary

Older adults with postprandial hypotension (PPH) experience reduced baroreflex effectiveness after meals, indicating a potential cause for fainting. This study highlights impaired baroreflex function in PPH patients.

Keywords:
AgingBaroreflex functionFallsPostprandial hypotensionSyncope

More Related Videos

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

21.6K
Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry
07:12

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Published on: January 19, 2020

9.8K

Related Experiment Videos

Last Updated: Dec 28, 2025

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
09:56

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

5.8K
Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

21.6K
Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry
07:12

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Published on: January 19, 2020

9.8K

Area of Science:

  • Gerontology
  • Cardiovascular Physiology
  • Autonomic Nervous System Function

Background:

  • Postprandial hypotension (PPH) is a frequent cause of fainting in the elderly, often linked to baroreflex dysfunction.
  • Age-related changes in autonomic regulation may contribute to PPH, but the precise mechanisms require further investigation.

Purpose of the Study:

  • To investigate baroreflex function in older adults with and without PPH during a standardized meal test.
  • To determine if age-related baroreflex dysfunction plays a role in the pathophysiology of PPH.

Main Methods:

  • Recruited 57 older adults (≥65 years), including 24 with PPH and 33 without (noPPH).
  • Conducted standardized meal tests and measured baroreflex effectiveness index (BEI) and baroreflex sensitivity (BRS) using the sequence method.

Main Results:

  • Baseline BEI and BRS were comparable between PPH and noPPH groups.
  • During meal tests, PPH subjects exhibited significantly lower BEI compared to noPPH subjects (p=0.042).
  • No significant difference was observed in the postprandial change in BRS between the groups.

Conclusions:

  • Older adults with PPH show an acute decrease in baroreflex effectiveness following meals.
  • This impaired baroreflex response during meal testing suggests a contributing mechanism for postprandial hypotension and associated fainting.