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The andro-accelerator hypothesis.

Sanjay Kalra1, Atul Dhingra2, Rakesh Sahay3

  • 1Department of Endocrinology, Bharti Hospital, Karnal, India.

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|February 18, 2020
PubMed
Summary
This summary is machine-generated.

Testosterone levels can rise in aging men due to external stimuli, according to the andro-accelerator hypothesis. This challenges the view of andropause as a disease, advocating for managing androgen imbalance instead.

Keywords:
ADAM, Andropause, Hypogonadism, Hypergonadism, Sexual offenders, #MeToo, Testosterone.

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Area of Science:

  • Endocrinology
  • Neuroendocrinology
  • Behavioral Science

Background:

  • Testosterone levels typically decline with age.
  • Middle-aged men sometimes exhibit inappropriate social behavior, suggesting hyperandrogenism.
  • The andro-accelerator hypothesis offers an alternative explanation for these observations.

Purpose of the Study:

  • To explain the phenomenon of apparent hyperandrogenism in aging men.
  • To discuss the andro-accelerator hypothesis and its implications.
  • To advocate for a new approach to managing androgen levels.

Main Methods:

  • Conceptual review of the andro-accelerator hypothesis.
  • Discussion of andro-conditioning via endocrine disruptors.
  • Exploration of clinical and public health relevance.

Main Results:

  • External stimuli (asexual and sexual) can accelerate testosterone production.
  • The hypothalamo-pituitary-testicular axis can be reset at a higher level.
  • Andro-conditioning involves endocrine disruptor stimuli or social content.

Conclusions:

  • The andro-accelerator hypothesis provides a framework for understanding age-related behavioral changes.
  • "Androequanimity" (androgen balance) should be the goal, not treating andropause as a disease.
  • Focusing on androgen imbalance is crucial for public health.