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Relapsed angioimmunoblastic T-cell lymphoma with large pericardial effusion
Rahul Sawhney1,2, Randy D Volkmer2, Barry Cooper1,2,3
1Department of Internal Medicine, Baylor University Medical CenterDallasTexas.
Proceedings (Baylor University. Medical Center)
|February 18, 2020
Summary
Peripheral T-cell lymphomas, including angioimmunoblastic T-cell lymphoma, can relapse. Prompt evaluation of B symptoms and effusions is crucial for patients with a history of this aggressive lymphoma.
Area of Science:
- Oncology
- Hematology
Background:
- T-cell lymphomas represent 10-15% of lymphoid malignancies, affecting T cells.
- Peripheral T-cell lymphomas (PTCLs) arise from mature T cells.
- Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of PTCL.
Observation:
- A patient with a history of AITL, previously treated with chemotherapy and autologous stem cell transplant, relapsed.
- The relapse presented with B symptoms and significant pericardial/pleural effusions.
- Pericardial tissue biopsy confirmed recurrent lymphoma.
Findings:
- Treatment with lenalidomide led to the resolution of effusions.
- The patient ultimately died from septic shock and multiorgan failure five months later.
Implications:
- This case underscores the importance of rapid assessment for B symptoms and new effusions in patients with a history of AITL.
- Timely intervention may be critical for managing relapsed angioimmunoblastic T-cell lymphoma.
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