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Related Experiment Video

Updated: Dec 28, 2025

Echocardiography-guided Injection for Targeted and Reliable Intramyocardial Stem Cell Delivery in a Rat Model of Myocardial Infarction

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Intramyocardial Injections to De-Stiffen the Heart: A Subject-Specific in Silico Approach.

Yaghoub Dabiri^1,2, Kevin L Sack^1,3, Semion Shaul¹

¹Department of Surgery, University of California San Francisco, San Francisco, California, USA.

Molecular & Cellular Biomechanics : MCB

|February 18, 2020

Summary

Minimally invasive injections of softening agents can globally de-stiffen the left ventricle (LV). Strategic regional myocardial softening effectively reduces LV stiffness, improving function in heart failure models.

Keywords:

HFpEF finite element modeling injection treatment myocardium subject-specific

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Published on: April 12, 2017

Area of Science:

Biomedical Engineering
Cardiovascular Research
Computational Biology

Background:

Stiff myocardium in the left ventricle (LV) impairs cardiac function.
Current treatments for LV stiffness are limited.
Minimally invasive approaches are needed to address myocardial stiffness.

Purpose of the Study:

To investigate if targeted injections of a softening agent can globally de-stiffen the left ventricle (LV).
To utilize physics-based models to design and optimize regional myocardial softening strategies.
To explore this approach for potential treatment of heart failure with preserved ejection fraction (HFpEF).

Main Methods:

Constructed physics-based finite element models of the LV using echocardiography and pressure data from swine.
Simulated intramyocardial injections of a softening agent at various locations and volumes.
Analyzed the impact of regional de-stiffening on global LV mechanics, including end-diastolic volume (EDV).

Main Results:

Regional myocardial de-stiffening led to global LV de-stiffening.
Injections into the free wall (8 ml) increased EDV by 15.0%; injections into septum and free wall (11 ml) increased EDV by 26.0%.
Endocardial injections resulted in EDV comparable to mid-wall and greater than epicardial injections, despite lower volume.

Conclusions:

In silico planning of regional myocardium de-stiffening can globally soften a stiff LV.
This subject-specific, minimally invasive strategy shows promise for treating HFpEF.
Further hypothesis-testing in animal models is warranted to validate simulation findings.