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Neutrophil/Lymphocyte Ratios, Platelet/Lymphocyte Ratios, and Mean Platelet Volume Values in Patients with Measles
Abdullah Solmaz1, Abit Demir1, Hüseyin Gümüş1
1Pediatrics, Harran University, Şanlıurfa, TUR.
Aim:
The purpose of this study was to compare neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) values of patients with measles within the healthy control group and then determine the utility of these parameters for determination of inflammatory situation in patients with measles.
Materials And Method:
A total of 51 pediatric patients who had visited Harran University Medical Faculty Pediatrics Clinic between June 2018 and May 2019 and who had been diagnosed with measles after anamnesis, clinical, and serological evaluations were included our study; 49 healthy children who visited our clinic for various reasons and had taken hemogram tests were also added to our study as the control group.
Results:
NLR and PLR values were observed higher than the control group for patients diagnosed with measles; however, the difference between the two groups was not statistically significant (p values 0.515 and 0.796, respectively). When MPV values of patients diagnosed with measles and control groups were compared, it was determined that MPV value was statistically lower in patients diagnosed with measles (p: 0.001).
Conclusion:
Based on the parameters obtained through our study, it can be said that NLR and PLR are not suitable parameters for proving inflammation in patients with measles but MPV can be used as a convenient parameter for that purpose. However, prospective studies conducted with more patients are needed in this respect.
Insights
Mean platelet volume (MPV) may indicate inflammation in measles patients, unlike neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). Further research with larger patient cohorts is recommended to confirm these findings.
Area of Science:
- Pediatrics
- Immunology
- Hematology
Background:
- Measles is a viral infection that can cause inflammation.
- Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) are hematological parameters that may reflect inflammatory states.
Purpose of the Study:
- To compare NLR, PLR, and MPV values in pediatric measles patients versus healthy controls.
- To assess the utility of these parameters in determining the inflammatory status of measles patients.
Main Methods:
- A case-control study involving 51 pediatric patients diagnosed with measles and 49 healthy children.
- Analysis of hemogram tests, including NLR, PLR, and MPV values.
Main Results:
- NLR and PLR were higher in measles patients but not statistically significant compared to controls.
- MPV values were significantly lower in measles patients than in the control group (p=0.001).
Conclusions:
- NLR and PLR are not suitable for indicating inflammation in measles.
- MPV is a potential convenient parameter for assessing inflammation in measles patients.
- Further prospective studies with larger sample sizes are needed.
