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Updated: Dec 28, 2025

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Published on: August 19, 2025
Empowering Clinical Diagnostics with Mass Spectrometry
1Department of Chemistry, Indian Institute of Science Education and Research Tirupati, Karakambadi Road, Tirupati 517507, India.
Mass spectrometry (MS) offers highly accurate disease diagnosis, advancing laboratory medicine. This powerful technology is increasingly used for early detection and therapy monitoring, improving public health outcomes.
Area of Science:
- Laboratory medicine
- Biomarker discovery
- Clinical diagnostics
Background:
- The need for accurate disease diagnosis drives innovation in laboratory medicine.
- Mass spectrometry (MS) is a key technology for discovering disease biomarkers.
- Current MS-based diagnostics are entering clinical practice, with more expected.
Purpose of the Study:
- To review the impact of mass spectrometry on clinical diagnosis.
- To highlight the growing importance of MS in public health.
Main Methods:
- Review of current literature on MS-based diagnostics.
- Analysis of MS technology's capabilities in molecular detection.
Main Results:
- MS offers ultrahigh sensitivity, specificity, and rapid molecular detection.
- MS is expanding the clinical diagnostic landscape.
- MS is becoming crucial for disease detection and therapy monitoring.
Conclusions:
- Mass spectrometry represents a new paradigm in clinical diagnosis.
- The role of MS in public health is rapidly increasing.
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