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Updated: Dec 28, 2025

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Potential microglia-based interventions for stroke.

Ling-Zhi Li¹, Yu-You Huang¹, Zhen-Hong Yang¹

¹Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.

CNS Neuroscience & Therapeutics

|February 18, 2020

Summary

This summary is machine-generated.

Stroke impacts many families globally. This review explores how microglia, the brain's immune cells, respond to stroke, considering age, sex, and cell interactions for better treatment strategies.

Keywords:

aging crosstalk microglia sex stroke therapy

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Last Updated: Dec 28, 2025

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Three-dimensional Confocal Analysis of Microglia/macrophage Markers of Polarization in Experimental Brain Injury

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Published on: September 4, 2013

Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation

Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation

Published on: February 16, 2018

Area of Science:

Neuroscience
Immunology
Stroke Research

Background:

Stroke imposes a significant global health burden.
Microglia are key brain immune cells responding to stroke.
Microglial roles are complex and influenced by aging and sex.

Purpose of the Study:

To review microglial dynamics in stroke.
To examine the influence of aging and sex on microglial function.
To explore cell-cell interactions and potential interventions.

Main Methods:

Literature review of microglial responses in stroke.
Analysis of aging and sex-specific alterations in microglia.
Investigation of neuro-immune cell crosstalk.

Main Results:

Microglia exhibit dynamic, context-dependent functions post-stroke.
Aging and sex significantly modulate microglial reactions.
Interactions with neurons and astrocytes are crucial for stroke pathology.

Conclusions:

Understanding age and sex differences in microglial responses is vital for stroke patient care.
Targeting microglial functions offers potential therapeutic avenues.
Further research into cell crosstalk can refine stroke interventions.