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Related Experiment Video

Updated: Dec 28, 2025

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Saccadic delay in multiple sclerosis: A quantitative description.

J A Nij Bijvank¹, A Petzold², D Coric³

¹Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Ophthalmology, Neuro-ophthalmology Expertise Center, Neuroscience Amsterdam, de Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Neurology, MS Center and Neuro-ophthalmology Expertise Center, Neuroscience Amsterdam, de Boelelaan 1117, Amsterdam, the Netherlands.

Vision Research

|February 18, 2020

Summary

This summary is machine-generated.

Multiple sclerosis (MS) patients exhibit delayed saccadic eye movements, impacting daily visual function. This saccadic delay worsens with disease progression and disability, highlighting its clinical relevance.

Keywords:

Eye movements Eye tracking Infrared oculography Multiple sclerosis Neuro-ophthalmology Saccades

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Last Updated: Dec 28, 2025

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Area of Science:

Ophthalmology
Neuroscience
Neurology

Background:

Eye movement disorders, including internuclear ophthalmoplegia (INO), are prevalent in multiple sclerosis (MS).
Infrared video-oculography offers a quantifiable method to assess these oculomotor abnormalities.

Purpose of the Study:

To characterize saccadic abnormalities in MS beyond INO.
To investigate the clinical relevance and associations of these saccadic parameters with disease characteristics and visual functioning.

Main Methods:

A cross-sectional study utilized the DEMoNS infrared oculography protocol to assess saccadic eye movements in 218 MS patients and 58 healthy controls across three tasks.
Logistic regression models were employed to analyze associations between saccadic parameters, disease duration, disability, and vision-related quality of life, adjusted for confounders.

Main Results:

MS patients demonstrated longer saccade latency compared to healthy controls across all tested tasks.
Increased saccadic delay correlated significantly with longer disease duration and higher disability scores in MS patients.
Saccadic delay was also significantly associated with a lower vision-related quality of life.

Conclusions:

Saccadic delay is a common finding in MS patients, extending beyond INO.
The degree of saccadic delay in MS is linked to disease severity and impacts daily visual functioning and quality of life.