Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ibuprofen in osteoarthritis.

J E Giansiracusa, M S Donaldson, M L Koonce

    Southern Medical Journal
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Management of cholecystitis.

    The Journal of the International College of Surgeons·2010
    Same author

    Diagnostic management of patients with jaundice.

    Journal of the American Medical Association·2010
    Same author

    Efficacy and safety of etoricoxib 30 mg and celecoxib 200 mg in the treatment of osteoarthritis in two identically designed, randomized, placebo-controlled, non-inferiority studies.

    Rheumatology (Oxford, England)·2006
    Same author

    Fibromyalgia syndrome improved using a mostly raw vegetarian diet: an observational study.

    BMC complementary and alternative medicine·2001
    Same author

    Continuity of care: a reconceptualization.

    Medical care research and review : MCRR·2001
    Same author

    Clinical efficacy of topical docosanol 10% cream for herpes simplex labialis: A multicenter, randomized, placebo-controlled trial.

    Journal of the American Academy of Dermatology·2001
    Same journal

    SMA's 6th Annual Physicians-in-Training Leadership Conference Abstract Presentations.

    Southern medical journal·2026
    Same journal

    Potential Impact of Lower Federal Loan Availability on Medical Education in Appalachia.

    Southern medical journal·2026
    Same journal

    Experiential Mentorship Skills Training: The Effect on Real-Life Mentoring.

    Southern medical journal·2026
    Same journal

    Social Pressure: How Early Social Context Shapes Career Interest in Medicine.

    Southern medical journal·2026
    Same journal

    Comparing Speed and Accuracy of Artificial Intelligence Large Language Models on the Orthopedic In-Training Examination.

    Southern medical journal·2026
    Same journal

    Don't Wait to Talk about Weight: A 2-Hour Interactive Curriculum Improves Medical Student Skills with Weight Management.

    Southern medical journal·2026
    See all related articles

    This study found that both ibuprofen and aspirin effectively treat osteoarthritis pain and improve function compared to placebo. Ibuprofen showed similar benefits to aspirin but with fewer gastrointestinal side effects.

    Area of Science:

    • Rheumatology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Osteoarthritis (OA) is a prevalent degenerative joint disease causing pain and disability.
    • Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for OA symptom management.
    • Comparing the efficacy and safety of different NSAIDs is crucial for optimal patient care.

    Purpose of the Study:

    • To compare the efficacy and tolerability of ibuprofen versus aspirin in patients with osteoarthritis.
    • To evaluate patient and physician-reported outcomes, including pain relief, functional improvement, and overall well-being.

    Main Methods:

    • A double-blind, multiclinic study involving 437 osteoarthritis patients.
    • Sequential treatment with ibuprofen (1,800 mg/day) or aspirin (3,600 mg/day), each followed by placebo for four weeks.

    Related Experiment Videos

  • Assessment of pain, function, general well-being, and gastrointestinal complaints.

    • Main Results:

    • Patients significantly preferred both ibuprofen and aspirin over placebo for pain relief, function, and well-being.
    • No statistically significant differences in efficacy were observed between ibuprofen and aspirin.
    • Ibuprofen demonstrated a similar incidence of gastrointestinal complaints to placebo and significantly fewer than aspirin.

    Conclusions:

    • Ibuprofen (1,800 mg/day) provides comparable antiarthritic benefits to aspirin (3,600 mg/day).
    • Both NSAIDs are superior to placebo in managing osteoarthritis symptoms.
    • Ibuprofen offers a favorable safety profile with reduced gastrointestinal side effects compared to aspirin.