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Macroporous Hydrogel Scaffolds with Tunable Physicochemical Properties for Tissue Engineering Constructed Using

Xiaoliang Qi1, Ting Su2, Mengying Zhang2

  • 1State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Xueyuan West Road, Lucheng District, Wenzhou 325027, China.

ACS Applied Materials & Interfaces
|February 19, 2020
PubMed
Summary

This study introduces a novel, eco-friendly method to create tunable polysaccharide hydrogels from salecan and κ-carrageenan for tissue engineering. These biocompatible hydrogels support cell growth and show promise for biomedical applications.

Keywords:
hydrogelspolysaccharidessalecantissue engineeringκ-carrageenan

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Polysaccharide hydrogels are promising for biomedical applications.
  • Existing polysaccharide hydrogels have limitations in mechanical properties and tunability for preclinical use.

Purpose of the Study:

  • To develop a simple, eco-friendly method for fabricating macroporous polysaccharide hydrogels.
  • To investigate the physicochemical properties and biocompatibility of salecan/κ-carrageenan hydrogels.
  • To demonstrate the potential of these hydrogels as scaffolds for tissue engineering.

Main Methods:

  • Fabrication of macroporous hydrogels using salecan and κ-carrageenan via an eco-friendly approach.
  • Evaluation of hydrogel physicochemical properties (viscoelasticity, morphology, swelling, thermal stability) by varying polysaccharide concentration.
  • In vitro assessment of hydrogel biocompatibility using mouse fibroblast cells (adhesion, migration, growth).
  • In vivo biocompatibility testing.

Main Results:

  • A macroporous polysaccharide hydrogel composed of salecan and κ-carrageenan was successfully fabricated using a non-toxic, eco-friendly method.
  • Hydrogel properties, including viscoelasticity, morphology, swelling, and thermal stability, were tunable by adjusting polysaccharide concentration.
  • The hydrogel supported fibroblast cell adhesion, migration, and proliferation in vitro.
  • The fabricated hydrogel demonstrated good biocompatibility in vivo.

Conclusions:

  • The developed salecan/κ-carrageenan hydrogel offers a tunable and biocompatible scaffold for tissue engineering.
  • This study presents a new strategy for optimizing polysaccharide-based hydrogels for biomedical applications.
  • The eco-friendly fabrication method avoids toxic chemicals, enhancing its applicability.