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Published on: August 21, 2021
A Self-Cascading Immunomodulatory Hydrogel for Remodeling Infected Diabetic Wounds.
Yulong Lan1,2, Xiaoliang Qi2, Jing Chen3
1College of Chemistry, Xiangtan University, Xiangtan, China.
Advanced Materials (Deerfield Beach, Fla.)
|June 2, 2026
Summary
A novel hydrogel treats diabetic foot ulcers by eradicating MRSA and reducing inflammation. This approach promotes healing by reprogramming immune cells and accelerating wound closure in diabetic foot ulcer models.
Area of Science:
- Biomaterials Science
- Immunology
- Regenerative Medicine
Background:
- Diabetic foot ulcers (DFUs) infected with MRSA are difficult to heal due to inflammation and impaired regeneration.
- Current treatments fail to address pathogen-associated molecular patterns (PAMPs) that sustain inflammation after bacterial death.
Purpose of the Study:
- To develop a self-cascading hypoglycemic immunomodulatory hydrogel for treating MRSA-infected DFUs.
- To simultaneously eliminate bacteria, neutralize PAMPs, and modulate the immune microenvironment.
Main Methods:
- Integration of Fe3O4@Au nanozymes with phenylboronic acid-modified hyaluronic acid and dopamine-functionalized silk fibroin.
- Utilizing endogenous glucose for cascade catalysis and near-infrared assistance for MRSA eradication.
- Employing catechol and boronic acid motifs to sequester PAMPs and suppress inflammatory signaling.
Main Results:
- Achieved >99.99% MRSA eradication with near-infrared assistance.
- Successfully reprogrammed M1 pro-inflammatory macrophages to M2 pro-healing phenotypes.
- Markedly accelerated wound closure in DFU models, with only 13.97% residual area after 14 days.
Conclusions:
- The developed hydrogel offers a coordinated antibacterial-immunomodulatory strategy for complex infected wounds.
- This approach establishes a new design paradigm coupling biocatalysis with immune regulation.
- Demonstrated potential for treating challenging MRSA-infected diabetic foot ulcers.
