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Updated: Dec 28, 2025

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
Published on: February 9, 2017
Using noisy or incomplete data to discover models of spatiotemporal dynamics.
Patrick A K Reinbold1, Daniel R Gurevich1, Roman O Grigoriev1
1School of Physics, Georgia Institute of Technology, Atlanta, Georgia 30332-0430, USA.
This study introduces a novel weak formulation approach for sparse regression, enabling accurate reconstruction of complex nonlinear partial differential equations (PDEs) even from noisy data. The method effectively handles high-order derivatives and latent variables, advancing dynamic system modeling.
Area of Science:
- Applied Mathematics
- Data Science
- Computational Physics
Background:
- Sparse regression is a powerful tool for uncovering dynamic system models from data.
- Traditional sparse regression methods struggle with noisy data, particularly when high-order derivatives are needed for nonlinear partial differential equations (PDEs).
- Accurate derivative estimation is crucial but often infeasible in the presence of noise.
Purpose of the Study:
- To develop a robust sparse regression approach for identifying complex dynamical systems from noisy data.
- To overcome the limitations of existing methods in handling high-order derivatives and latent variables in PDE discovery.
- To demonstrate the efficacy of the proposed method on challenging benchmark problems and real-world fluid dynamics.
Main Methods:
- A novel weak formulation of the sparse regression problem is proposed.
- This approach avoids direct computation of high-order derivatives, mitigating noise sensitivity.
- The method is applied to reconstruct nonlinear PDEs, including the Kuramoto-Sivashinsky equation, and models with unobserved latent variables.
Main Results:
- Accurate reconstruction of PDEs with high-order derivatives from significantly noisy data.
- Successful identification of PDE models involving latent variables, such as those in weakly turbulent fluid flow.
- Demonstrated robustness and generality of the weak formulation approach.
Conclusions:
- The weak formulation offers a general and effective solution for sparse regression in the presence of noisy data.
- This method significantly enhances the ability to discover complex dynamical systems, including those with unmeasured components.
- The approach holds promise for advancing scientific discovery in fields relying on data-driven modeling of complex dynamics.
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