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Updated: Dec 28, 2025

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
Published on: February 9, 2017
Using noisy or incomplete data to discover models of spatiotemporal dynamics
Patrick A K Reinbold1, Daniel R Gurevich1, Roman O Grigoriev1
1School of Physics, Georgia Institute of Technology, Atlanta, Georgia 30332-0430, USA.
Abstract:
Sparse regression has recently emerged as an attractive approach for discovering models of spatiotemporally complex dynamics directly from data. In many instances, such models are in the form of nonlinear partial differential equations (PDEs); hence sparse regression typically requires the evaluation of various partial derivatives. However, accurate evaluation of derivatives, especially of high order, is infeasible when the data are noisy, which has a dramatic negative effect on the result of regression. We present an alternative and rather general approach that addresses this difficulty by using a weak formulation of the problem. For instance, it allows accurate reconstruction of PDEs involving high-order derivatives, such as the Kuramoto-Sivashinsky equation, from data with a considerable amount of noise. The flexibility of our approach also allows reconstruction of PDE models that involve latent variables which cannot be measured directly with acceptable accuracy. This is illustrated by reconstructing a model for a weakly turbulent flow in a thin fluid layer, where neither the forcing nor the pressure field is known.
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