Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electrocardiogram Fundamentals01:28

Electrocardiogram Fundamentals

524
Introduction
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
524
Fast Decoupled and DC Powerflow01:24

Fast Decoupled and DC Powerflow

176
The fast decoupled power flow method addresses contingencies in power system operations, such as generator outages or transmission line failures. This method provides quick power flow solutions, essential for real-time system adjustments. Fast decoupled power flow algorithms simplify the Jacobian matrix by neglecting certain elements, leading to two sets of decoupled equations:
176

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computing chaotic time-averages from few periodic or non-periodic orbits.

Chaos (Woodbury, N.Y.)·2025
Same author

Physically informed data-driven modeling of active nematics.

Science advances·2023
Same author

Observing a dynamical skeleton of turbulence in Taylor-Couette flow experiments.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2023
Same author

Robust learning from noisy, incomplete, high-dimensional experimental data via physically constrained symbolic regression.

Nature communications·2021
Same journal

Exploring mechanisms for reversal of flow in tunicate hearts.

Chaos (Woodbury, N.Y.)·2026
Same journal

State estimation in spatiotemporal chaos via low-rank StatFEM.

Chaos (Woodbury, N.Y.)·2026
Same journal

Universal response functions in driven dissipative tunneling dynamics.

Chaos (Woodbury, N.Y.)·2026
Same journal

A network-based approach to characterize the dynamics of the coupling field of thermoacoustic oscillators in annular geometry.

Chaos (Woodbury, N.Y.)·2026
Same journal

Data-driven soliton manifold approximations for dark and bright waves: Some prototypical 1D case examples.

Chaos (Woodbury, N.Y.)·2026
Same journal

Gap junction architecture and synchronization clusters in the thalamic reticular nuclei.

Chaos (Woodbury, N.Y.)·2026
See all related articles

Related Experiment Video

Updated: Jun 8, 2025

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
08:43

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

Published on: August 26, 2021

2.4K

Ultra-low-energy defibrillation through adjoint optimization.

Alejandro Garzón1, Roman O Grigoriev2

  • 1Department of Mathematics, Universidad Sergio Arboleda, Bogotá 110221, Colombia.

Chaos (Woodbury, N.Y.)
|November 4, 2024
PubMed
Summary
This summary is machine-generated.

A single, precisely timed defibrillation pulse can be more effective than sequential low energy antitachycardia pacing (LEAP). Adjoint optimization drastically reduces defibrillation energy, exploiting cardiac tissue dynamics for improved outcomes.

More Related Videos

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.4K
A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

26.2K

Related Experiment Videos

Last Updated: Jun 8, 2025

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
08:43

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

Published on: August 26, 2021

2.4K
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.4K
A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

26.2K

Area of Science:

  • Computational Biology
  • Cardiac Electrophysiology
  • Medical Device Technology

Background:

  • Defibrillation is critical for treating cardiac arrhythmias.
  • Current defibrillation protocols, including low energy antitachycardia pacing (LEAP), require significant energy.
  • Optimizing defibrillation energy is crucial for patient safety and device longevity.

Purpose of the Study:

  • To investigate ultra-low-energy defibrillation protocols.
  • To compare the efficacy of single biphasic pulses versus LEAP.
  • To explore energy reduction strategies using computational modeling.

Main Methods:

  • Utilized a two-dimensional cardiac tissue model.
  • Investigated the effectiveness of single, properly timed biphasic pulses.
  • Employed adjoint optimization techniques to minimize energy requirements.
  • Analyzed the role of vulnerable windows and phase singularity annihilation.

Main Results:

  • A single, timed biphasic pulse demonstrated superior defibrillation efficacy compared to LEAP.
  • Adjoint optimization reduced defibrillation energy by three orders of magnitude below LEAP levels.
  • Exploited tissue dynamics in vulnerable windows to achieve energy reduction.

Conclusions:

  • Ultra-low-energy defibrillation is achievable through optimized single-pulse protocols.
  • Adjoint optimization offers a powerful method for minimizing defibrillation energy.
  • Understanding cardiac tissue dynamics is key to developing more efficient defibrillation strategies.