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Related Concept Videos

Preparation of Samples for Electron Microscopy01:20

Preparation of Samples for Electron Microscopy

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To be visualized by an electron microscope, either transmission or scanning, biological samples need to be fixed (stabilized) so the electron beam does not destroy them and dried thoroughly (desiccated/dehydrated) so the vacuum does not affect them. Fixation needs to be done as quickly as possible because the sample properties will start changing as soon as it is removed from its natural environment. For example, in a tissue sample, the oxygen levels begin decreasing, causing an altered...
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Cryo-electron Microscopy01:28

Cryo-electron Microscopy

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Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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Related Experiment Video

Updated: Dec 28, 2025

Cryogenic Sample Loading into a Magic Angle Spinning Nuclear Magnetic Resonance Spectrometer that Preserves Cellular Viability
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A new material of cryopreserving cell samples.

Tiantian Liu1, Duo Xu2, Rong Zhou2

  • 1School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510310, China.

Cryobiology
|February 20, 2020
PubMed
Summary

A new cryopreservation product, BioFlash Drive™ SP, simplifies cell freezing without compromising cell viability. This method is less time-consuming and manual, making cell archiving more accessible for researchers.

Keywords:
BiospecimensCell freezingCryopreservationHEp-2VeroViability

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Area of Science:

  • Cell Biology
  • Cryobiology
  • Biotechnology

Background:

  • Cryopreservation is essential for storing biological samples in research.
  • Traditional cell freezing protocols are complex and time-consuming.

Purpose of the Study:

  • To evaluate a new, simplified cryopreservation product, BioFlash Drive™ SP.
  • To compare its efficacy with conventional cell freezing methods.

Main Methods:

  • Tested BioFlash Drive™ SP with Vero and HEp-2 cell lines.
  • Compared post-thaw cell viability against standard cryopreservation protocols.

Main Results:

  • No statistically significant difference in cell viability was observed.
  • The BioFlash Drive™ SP method proved less manual and time-consuming.

Conclusions:

  • The BioFlash Drive™ SP offers a simplified, reliable alternative for cell cryopreservation.
  • Easier cell archiving may enable more frequent documentation of research progress.