Implantable Sensor for Detecting Changes in the Loss Tangent of Cerebrospinal Fluid

The increasing utilization of cerebrospinal fluid (CSF) in early detection of Alzheimer's disease (AD) is attributed to the change of Amyloid- β proteins. Since, the brain is suspended in CSF, changes of Amyloid- β proteins in CSF reflect a pathophysiological variation of the brain due to AD. However, the correlation between Amyloid- β proteins and the dielectric properties (DPs) of CSF is still an open question. This paper reports the characterized DPs of CSF collected from canines using lumbar punctures. The CSF samples from canines show a strong correlation with respect to human in terms of the loss tangent, which indicates suitability of using canines as translational primates. Amyloid- β [ Aβ(1-40) and Aβ(1-42)] proteins associated with AD were added to CSF samples in order to emulate AD condition. The results of emulated AD condition suggest a decrease in the relative permittivity and increase in the loss tangent. To detect changes in the loss tangent of CSF, which combines both relative permittivity and conductivity, a developed sensor is proposed. The designed sensor consists of a voltage controlled oscillator (VCO) and implantable antenna, which exhibits a wideband and low quality factor to be stable with respect to changes in the loss tangent of CSF. The measurements of the received power levels from the sensor in different liquid-based phantoms having different loss tangent values were used to correlate changes in the loss tangent. The developed correlation model is able to predict the loss tangent based on the received power level, which can be used to detect changes in the loss tangent of CSF due to AD. Consequently, this approach could be used as an early diagnosis of AD.