Jove
Visualize
Contact Us

Related Experiment Videos

Plasma catecholamine levels in severe atopic eczema.

G Ionescu1, R Kiehl

  • 1Research Department, Spezialklinik Neukirchen, West Germany.

Allergy
|November 1, 1988
PubMed
Summary

Patients with severe atopic eczema have higher circulating norepinephrine levels compared to healthy individuals. This study investigated plasma catecholamines in atopic eczema patients, finding significant norepinephrine elevation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide profiles indicate wolf population connectivity within the eastern Carpathian Mountains.

Genetica·2019
Same author

Search for lepton flavour violation in the <i>eμ</i> continuum with the ATLAS detector in [Formula: see text]<i>pp</i> collisions at the LHC.

The European physical journal. C, Particles and fields·2015
Same author

Search for dilepton resonances in pp collisions at √s=7 TeV with the ATLAS detector.

Physical review letters·2012
Same author

Search for a standard model Higgs boson in the H→ZZ→ℓ(+)ℓ(-)νν decay channel with the ATLAS detector.

Physical review letters·2011
Same author

Search for the Higgs boson in the H→WW→lνjj decay channel in pp collisions at √s=7 TeV with the ATLAS detector.

Physical review letters·2011
Same author

Intermuscular and subcutaneous adipose tissue distributions differ in HIV+ versus HIV-men and women.

International journal of body composition research·2011
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Biochemistry
  • Immunology
  • Dermatology

Background:

  • Atopic eczema is a chronic inflammatory skin condition.
  • Dysregulation of the autonomic nervous system is implicated in atopic diseases.
  • Plasma catecholamine levels in severe atopic eczema require further investigation.

Purpose of the Study:

  • To compare plasma catecholamine concentrations between patients with severe atopic eczema and healthy controls.
  • To investigate potential alterations in norepinephrine, epinephrine, and dopamine in atopic eczema.

Main Methods:

  • Standardized High-Performance Liquid Chromatography (HPLC) was used for catecholamine measurement.
  • Plasma samples were analyzed from 41 adult patients with severe atopic eczema.
  • Plasma samples were also analyzed from 18 healthy adult volunteers.

Main Results:

  • Significantly elevated circulating norepinephrine levels were observed in the atopic eczema group (P < 0.005).
  • Minimal differences in epinephrine and dopamine concentrations were found between the groups.
  • Dopamine beta-hydroxylase (DBH) activities were normal in the atopic group.

Conclusions:

  • Severe atopic eczema is associated with increased plasma norepinephrine.
  • The findings suggest a specific alteration in catecholamine metabolism or release in atopic eczema.
  • Further research is needed to elucidate the mechanisms behind elevated norepinephrine in atopic eczema, considering normal DBH activity.

Related Experiment Videos