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Updated: Dec 28, 2025

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
Published on: September 29, 2016
A role for low concentration reaction intermediates in the signal amplification by reversible exchange process
Marianna Fekete1, Soumya S Roy, Simon B Duckett
1Centre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of York, Heslington, York, YO10 5NY, UK. simon.duckett@york.ac.uk.
Abstract:
A route to monitor the involvement of less abundant species during the catalytic transfer of hyperpolarisation from parahydrogen into a substrate is detailed. It involves probing how the degree of hyperpolarisation transfer catalysis is affected by the magnetic field experienced by the catalyst during this process as a function of temperature. The resulting data allow the ready differentiation of the roles played by hard to detect and highly reactive complexes, such as [Ir(H)2(NHC)(substrate)2(methanol)]Cl, from dominant species such as [Ir(H)2(NHC)(substrate)3]Cl. The difference in behaviour results from changes in the interligand spin-spin coupling network within the active SABRE catalysts.
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