Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contribution of Risk Factors, Including Polygenic Score, to the Multifactorial Risk Assessment for the Implementation of Personalized Breast Cancer Screening: Insights from the PERSPECTIVE: Integration and Implementation Project.

Cancers·2026
Same author

Longitudinal Profiling of Cervical Cancers Reveals Therapy-Induced Vulnerabilities Beyond the Checkpoint.

Cancer research·2026
Same author

Molecular Classification Refines Adjuvant Radiation Therapy Use in Stage III Endometrial Cancer Exhibiting No Specific Molecular Profile.

Practical radiation oncology·2026
Same author

Cultryx: Precision Diagnostic Stewardship for Blood Cultures Using Machine Learning.

medRxiv : the preprint server for health sciences·2026
Same author

In response to Daungsupawong and Wiwanitkit.

Brachytherapy·2026
Same author

Protocol for targeted peripheral adeno-associated viral vector transduction of the intradental neurons in mice.

STAR protocols·2026

Related Experiment Video

Updated: Dec 28, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K

Improvement in Patient-Reported Outcomes With Intensity-Modulated Radiotherapy (RT) Compared With Standard RT: A

Anamaria R Yeung1, Stephanie L Pugh2, Ann H Klopp3

  • 1University of Florida, Gainesville, FL.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|February 20, 2020
PubMed
Summary

Patients reported more gastrointestinal (GI) adverse events (AEs) than clinicians during radiotherapy (RT). Patient-reported outcomes (PROs) revealed intensity-modulated RT (IMRT) reduced GI AEs compared to standard RT, highlighting the importance of PROs in oncology trials.

More Related Videos

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.6K
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

14.7K

Related Experiment Videos

Last Updated: Dec 28, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K
Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.6K
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

14.7K

Area of Science:

  • Oncology
  • Clinical Trials
  • Patient-Reported Outcomes

Background:

  • The National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) is standard for oncology AE reporting.
  • CTCAE may underreport patient-symptom experiences.
  • This study compared patient and clinician reporting of symptoms during radiotherapy (RT).

Purpose of the Study:

  • To compare patient-reported outcomes (PROs) using the PRO-CTCAE with clinician-reported adverse events (AEs) during RT.
  • To assess differences in symptom reporting between standard RT and intensity-modulated RT (IMRT).

Main Methods:

  • Patients with cervical or endometrial cancer undergoing postoperative RT were randomized to standard 4-field RT or IMRT.
  • Patients completed the PRO-CTCAE for GI toxicity (abdominal pain, diarrhea, fecal incontinence).
  • Clinicians recorded AEs using CTCAE grading; patient and clinician reports were compared.

Main Results:

  • Patients reported high-grade abdominal pain (19.1%), diarrhea (38.5%), and fecal incontinence (6.8%) more frequently than clinicians.
  • IMRT was associated with fewer patient-reported high-grade GI AEs (diarrhea, fecal incontinence) compared to standard RT at 5 weeks.
  • Clinician reports showed no difference in AEs between IMRT and standard RT arms.

Conclusions:

  • Patient-reported AEs (PROs) revealed a reduction in GI symptoms with IMRT compared to standard RT.
  • Clinician reporting underestimated symptomatic GI AEs compared to patient reports.
  • Incorporating patient-reported symptomatic AEs is crucial for accurate assessment in this patient population.