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Management of Cyclosporine-Influenced Gingival Enlargement With Azithromycin
Satish S Kumar1, Husain Mohammad2,3, Kian Kar4
1Department of Periodontics, Arizona School of Dentistry and Oral Health, A. T. Still University, Mesa, AZ.
Introduction:
Management of drug-influenced gingival enlargement is challenging, and surgery is most often indicated. However, because of a unique mechanism of action, azithromycin helps in the management of gingival enlargement caused by cyclosporine. An incidental observation of the effect of azithromycin in the cyclosporine-influenced gingival enlargement by physicians in 1995 led to series of basic investigations and clinical trials confirming this observation and providing a non-surgical treatment modality.
Case Presentation:
In this report, successful management of cyclosporine-influenced gingival enlargement in a 39-year-old renal transplant patient with the use of azithromycin without any surgical intervention is presented.
Conclusion:
Use of azithromycin for managing cyclosporine-influenced gingival enlargement is a useful alternative or adjunct to surgical management. It is hoped that this report will raise further awareness of this non-surgical modality in patients taking cyclosporine.
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