Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An improved synthesis of the saponin, polyphyllin D.

Carbohydrate research·2001
Same author

A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality.

The Journal of clinical investigation·2001
Same author

Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine.

The New England journal of medicine·2001
Same author

MHC-independent allograft vascular disease: mRNA profile in the MHC congenic rat heterotopic cardiac transplant model.

Transplantation proceedings·2001
Same author

Endothelin is a potent inhibitor of matrix metalloproteinase-2 secretion and activation in rat mesangial cells.

American journal of physiology. Renal physiology·2001
Same author

[Morphological studies of myocardial fibrosis in different types of Keshan disease].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2001
Same journal

[The era of precision diagnosis and treatment for optic neuritis: advances in diagnostic classification, biomarkers and therapeutic strategies].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
Same journal

[Application value of ocular multimodal imaging methods in the evaluation of increased intracranial pressure].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
Same journal

[Secondary panuveitis after ocular wasp sting: a case report].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
Same journal

[Correlation of ocular surface changes with filtering bleb morphology after antiglaucoma surgery for primary angle-closure glaucoma].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
Same journal

[Regulation of SARM1 on SNPH expression and its participation in glaucomatous optic neuropathy].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
Same journal

[Construction of a regulated <i>Crat</i> overexpression system in mouse hippocampal neuronal HT22 cell line].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2026
See all related articles

Related Experiment Video

Updated: Dec 28, 2025

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

19.9K

[Research progress of outer retinal tabulation].

B Li1, Y Y Chen1

  • 1Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|February 20, 2020
PubMed
Summary
This summary is machine-generated.

Outer retinal tubular structures (ORTs) are pathological retinal remodeling common in advanced retinal diseases like age-related macular degeneration. Awareness of ORTs is crucial for accurate diagnosis and prognosis, as they indicate poor visual outcomes.

Keywords:
AtrophyPhotoreceptor cellsRetinal photoreceptor cell outer segmentTomography, optical coherence

More Related Videos

Author Spotlight: Using the Split Retina Technique for Enhanced Access and Accelerated Experiments
07:53

Author Spotlight: Using the Split Retina Technique for Enhanced Access and Accelerated Experiments

Published on: January 16, 2024

5.3K
Author Spotlight: Efficient Retinal Ganglion Cell Counting in Mouse Models of Glaucoma for Treatment Evaluation
05:52

Author Spotlight: Efficient Retinal Ganglion Cell Counting in Mouse Models of Glaucoma for Treatment Evaluation

Published on: October 4, 2024

1.6K

Related Experiment Videos

Last Updated: Dec 28, 2025

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

19.9K
Author Spotlight: Using the Split Retina Technique for Enhanced Access and Accelerated Experiments
07:53

Author Spotlight: Using the Split Retina Technique for Enhanced Access and Accelerated Experiments

Published on: January 16, 2024

5.3K
Author Spotlight: Efficient Retinal Ganglion Cell Counting in Mouse Models of Glaucoma for Treatment Evaluation
05:52

Author Spotlight: Efficient Retinal Ganglion Cell Counting in Mouse Models of Glaucoma for Treatment Evaluation

Published on: October 4, 2024

1.6K

Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Pathology

Background:

  • Outer retinal tubular structures (ORTs) are observed on spectral-domain coherence tomography (SD-OCT).
  • ORTs represent a form of outer retinal remodeling, particularly involving photoreceptors, under pathological conditions.
  • They are frequently associated with advanced retinal degenerative diseases, including neovascular age-related macular degeneration.

Purpose of the Study:

  • To elucidate the nature and clinical significance of outer retinal tubular structures (ORTs).
  • To differentiate ORTs from intraretinal fluid or cystoid edema on SD-OCT.
  • To emphasize the importance of recognizing ORTs for guiding clinical management and prognosis.

Main Methods:

  • Morphological analysis of ORTs using spectral-domain coherence tomography (SD-OCT).
  • Histopathological examination to understand the underlying retinal changes.
  • Review of clinical data and treatment responses in patients with ORTs.

Main Results:

  • ORTs present as round or oval structures with reflective borders and lumens in the outer nuclear layer.
  • Histopathology confirms ORTs as retinal remodeling, signifying advanced outer retinal damage.
  • ORTs are distinct from intraretinal fluid and do not indicate neovascular activity, showing poor response to anti-VEGF therapy.

Conclusions:

  • Outer retinal tubular structures are indicators of severe retinal damage and a common endpoint for various degenerative diseases.
  • Misinterpreting ORTs as signs of active neovascularization can lead to inappropriate treatment.
  • Increased awareness and accurate identification of ORTs are vital for appropriate clinical decision-making and patient prognosis.