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Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties
Joana Couto1, Artur Figueirinha1,2, Maria Teresa Batista1,3,4
1Faculty of Pharmacy of University of Coimbra, University of Coimbra, 3000-548 Coimbra, Portugal.
Antioxidants (Basel, Switzerland)
|February 21, 2020
Summary
Wild strawberry (Fragaria vesca) leaf extract demonstrates significant antioxidant properties. Its hydrogel formulation is safe and effective for topical application, offering cutaneous compatibility and antioxidant benefits.
Area of Science:
- Phytochemistry and Cosmeceuticals
- Dermatology and Skin Health
Background:
- Fragaria vesca L. (wild strawberry) is recognized for its bioactive compounds, including flavonoids and ellagitannins.
- Traditional uses suggest F. vesca leaves possess antiseptic, emollient, and dermatological protective properties.
Purpose of the Study:
- To optimize the extraction of bioactive compounds from F. vesca leaves.
- To characterize the antioxidant and cytotoxic potential of F. vesca extracts.
- To evaluate the safety, stability, and efficacy of a F. vesca hydrogel formulation for topical use.
Main Methods:
- Optimized extraction of F. vesca, followed by HPLC characterization.
- In vitro assays for ROS scavenging activity, cytotoxicity (HaCaT cells), and tyrosinase inhibition.
- Formulation of a 2% hydroxyethylcellulose hydrogel with F. vesca extract, followed by physicochemical, stability, cytotoxicity, and ROS scavenging assessments.
- In vivo studies including human repeat insult patch testing (HRIPT) and antioxidant efficacy assays.
Main Results:
- F. vesca extracts exhibited notable antioxidant activity.
- The F. vesca hydrogel formulation demonstrated good physicochemical properties, stability, and safety.
- In vivo and in vitro tests confirmed the hydrogel's cutaneous compatibility, acceptability, and antioxidant efficacy.
Conclusions:
- Optimized F. vesca extracts possess significant antioxidant potential.
- The developed F. vesca hydrogel is a stable and safe topical formulation.
- The hydrogel formulation is suitable for skin application, providing antioxidant benefits and demonstrating good tolerability.
