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Analysis of Multiple Factors Involved in Pertussis-Like Coughing

Jiaying Cao1,2, Lu Xu1, Jiahua Pan1,2

  • 1Anhui Medical University, Hefei, China.

Clinical Pediatrics
|February 21, 2020
PubMed

Insights

Bordetella pertussis infection, high white blood cell (WBC) count, and elevated lymphocyte ratio are key indicators of a poor prognosis in children with pertussis-like coughing, requiring prompt medical attention.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Pertussis-like coughing in children can have varied durations and outcomes.
  • Identifying prognostic factors is crucial for effective management and resource allocation.

Purpose of the Study:

  • To determine the risk factors associated with the prognosis of pertussis-like coughing in hospitalized children.
  • To identify independent predictors of prolonged illness or relapse.

Main Methods:

  • Retrospective study of 213 children hospitalized with pertussis-like coughing (2018-2019).
  • Data collected included demographics, vaccination status, clinical symptoms, complications, pathogens, WBC count, lymphocyte ratio, and treatments.
  • Logistic regression analysis was employed to identify risk factors.

Main Results:

  • Over 10% of children experienced symptoms lasting longer than 3 months.
  • Bordetella pertussis infection was significantly associated with poor prognosis (P < .05).
  • Elevated white blood cell (WBC) count (>20 × 10^9/L) and lymphocyte ratio (>60%) were also linked to poorer outcomes.

Conclusions:

  • Bordetella pertussis, high WBC count, and elevated lymphocyte ratio are independent risk factors for poor prognosis in pediatric pertussis-like coughing.
  • These factors can aid in predicting disease severity and guiding treatment strategies.
  • Further research may explore specific interventions for high-risk pediatric patients.

Keywords:
infantspertussis-like coughingprognosisrisk factors

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