Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 10, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

Cardiac unloading models for myocardial reverse remodeling.

Xinjie Xu1, Yukun Luo2, Tao Lei1

  • 1State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Basic Research in Cardiology
|July 8, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new option for monitoring heart failure. First experience in Spain with CardioMEMS.

Medicina clinica·2020
Same author

Trends in Short- and Long-Term ST-Segment-Elevation Myocardial Infarction Prognosis Over 3 Decades: A Mediterranean Population-Based ST-Segment-Elevation Myocardial Infarction Registry.

Journal of the American Heart Association·2020
Same author

Previously Undetected Obstructive Sleep Apnea in Patients With New-Onset Atrial Fibrillation.

The American journal of cardiology·2020
Same author

Short-term changes in left and right systolic function following ferric carboxymaltose: a substudy of the Myocardial-IRON trial.

ESC heart failure·2020
Same author

Author Correction: Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status.

Scientific reports·2020
Same author

Soluble ST2 and Diuretic Efficiency in Acute Heart Failure and Concomitant Renal Dysfunction.

Journal of cardiac failure·2020
This summary is machine-generated.

Myocardial reverse remodeling (RR) recovery of the failing heart improves prognosis. Left ventricular assist devices (LVADs) powerfully induce RR, and experimental models are crucial for understanding cardiac recovery and developing new therapies.

Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Myocardial reverse remodeling (RR) signifies heart recovery, improving long-term outcomes.
  • Left ventricular assist devices (LVADs) are potent inducers of RR through mechanical unloading.
  • LVADs have transformed end-stage heart failure treatment and prognosis.

Purpose of the Study:

  • To review the relationship between mechanical load and myocardial phenotypes in unloading models.
  • To discuss how unloading models aid in understanding RR mechanisms.
  • To explore the development of novel therapies for heart failure.

Main Methods:

  • Systematic review of existing literature on myocardial unloading models.
  • Analysis of findings from human samples and experimental unloading models.
Keywords:
DeTACHeterotopic transplantationLeft ventricular assist deviceModelReverse remodelingUnloading

More Related Videos

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

Related Experiment Videos

Last Updated: Jul 10, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

  • Discussion of the role of mechanical unloading in cardiac pathophysiology.

    • Main Results:

    • LVADs demonstrate the strongest capacity for mechanical unloading and inducing RR.
    • Paired patient samples from LVAD therapy offer a unique model for RR research.
    • Experimental unloading models provide essential validation and novel perspectives.

    Conclusions:

    • Reproducible myocardial unloading models are vital for studying RR mechanisms.
    • These models are foundational for developing new therapeutic strategies for heart failure.
    • Understanding mechanical unloading is key to improving patient outcomes in heart failure.